詳細は不明ですが、出題された英文は、
Structural Variation in the Human Genome
NEJM Volume 356:1169-1171 March 15, 2007 Number 11
[Extract]
The completion of the Human Genome Project was a remarkable feat and provided 3 billion bases of reference nucleotides for comparative studies. An analogy often used to conceptualize human genetic information is that of an encyclopedia, in which each volume of the set would represent 1 of the 23 pairs of human chromosomes. Sections within each volume would represent the (approximately) 25,000 genes of the human genome, and letters of the alphabet would represent the individual bases of DNA encoding specific amino acids that are the building blocks of proteins. To date, the molecular medicine model that is promulgated in . . .
http://content.nejm.org/cgi/content/extract/356/11/1169
であったとのこと。受講生が教材にしてほしいと選んでくれた記事でした(指導ではあつかわず、選んだ本人も受験せず)。
なお、同号で指導であつかったのは、
What Genome-wide Association Studies Can Do for Medicine
Kaare Christensen, M.D., Ph.D., and Jeffrey C. Murray, M.D.
[Extract]
As researchers have explored the environmental and inherited causes of common diseases, they have often amassed clinical and laboratory data collected from people with common complex disorders. Many have also collected biologic material, including DNA. These resources represent an essential component for ferreting out genes relevant to disease with the use of the genome-wide association study. This method entails the matching of a given human genome sequence with an annotated, high-resolution map of common genetic variation; it benefits from a large collection of DNA samples obtained from a population whose clinical characteristics are well defined, as well as cost-effective genotyping . . .
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